HO-1 在肝肾疾病中的作用研究进展

血红素氧合酶是血红素降解的限速酶,与酶解产物胆红素、CO-道,共同发挥着抗氧化、抗炎、抑制细胞凋亡、改善组织微循环等作用。血红素氧合酶1是血红素氧合酶的诱导型在脓毒血症、高血压、急性肺损伤等多种疾病中均呈现适应性诱导表达并产生相应的细胞保护作用在肝脏缺血再灌注损伤、肝硬化、肝衰竭、肝移植、急性肾损伤、移植肾损伤等疾病中也发挥着细胞保护作用。本文综述了近年来血红素氧合酶1在肝肾疾病中作用的研究进展,以期为未来治疗方法带来新突破。

The Development of the Role of HO-1 in Liver and Kidney Disease

The heme oxygenase, as a rate limiting enzyme in the process of heme degradation, plays an important role in antioxidant, anti-inflammatory, inhibiting cell apoptosis and improving tissue microcirculation together with the hydrolysates of bilirubin, CO. Heme oxygenase 1, an inducible heme oxygenase, can be adaptively induced and cytoprotective in septicopyemia, hypertension, acute lung injury and other diseases. The cytoprotective effect of heme oxygenase 1 can also be seen in the hepatic ischemia reperfusion injury, liver cirrhosis, hepatic failure, liver transplantation, acute kidney injury as well as renal allograft injury. The recent development of the role of heme oxygenase 1 in liver and kidney disease is reviewed in order to discuss the possible new breakthrough for future therapies.