液氮冷冻联合兰科肤宁治疗孕妇尖锐湿疣的临床效果评价

目的:评价液氮冷冻联合兰科肤宁治疗孕妇尖锐湿疣的临床疗效与安全性。方法:回顾性分析我院收治的46例患有尖锐湿疣的孕妇,平均年龄为27岁,妊娠平均18周。每例患者的病灶数为5~18个。应用液氮枪喷涂于皮损,液氮枪距皮损2-3 cm,喷雾时间60秒,重复操作直至喷嘴霜化。将蓝科肤宁喷涂于单层纱布,敷于皮损部位20分钟,每天2-3次,共1周。分别于治疗后1月、3月观察皮损愈合情况,评价治疗效果。结果:治疗5天后,皮损均治愈,所有患者除有轻度至中度疼痛外,无其他不适。治疗后1个月,满意度94%;治疗后3个月,满意度为87%。无色素脱失或瘢痕形成,无任何严重不良事件。每位孕妇均分娩出一个健康的婴儿,无分娩相关并发症。治疗后1个月,只有1例病人复发,复发率为2.2%。治疗后3月,5例复发,复发率为10.9%。结论:液氮冷冻联合蓝科肤宁治疗孕妇尖锐湿疣的近期疗效较好,安全性较高。

Evaluation of the Clinical Effect of Cryotherapy Combined with Lankefuning on the Pregnant Women with Condyloma Acuminata

ABSTRACT Objective: To evaluate the clinical effect and safety of cryotherapy combined with Lankefuning on the pregnant women with condyloma acuminate (CA). Methods: In this study, 46 cases of pregnant women with CA were treated with cryotherapy combined with Lankefuning. The mean age was 27 years(range, 23-34 years) and the patients were diagnosed with CA at a mean of 18 weeks (range, 10-26 weeks) gestation. The liquid nitrogen gun sprays liquid nitrogen to the lesions until the wart color changes from flesh colored to purple. The spray time was >60 sec and continued until the nozzle frosted (~2 min) and the nitrogen spray was no longer able to focus on the lesions. Then PC was sprayed on the non-woven fabric or single-layer gauze and applied to the affected area for 20 min, 2-3 times a day and for a period of one week. After three sessions, all patients were followed up for clinical evaluation at one months and three months. Results: The lesions were healed at 5 days after the treatment. All patients reported no discomfort, with the exception of mild to moderate pain. There was no visible warts after three sessions of cryotherapy and Lankefuning treatment. All patients were able to follow the treatment protocol, and responded to the survey with 94% satisfaction at 1 month and 87% satisfaction at 3 months after the completion of treatment. In one month'' follow-up, only one case of recurrence was identified, and the recurrence rate was 2.2%. At three months, five cases of recurrence were identified, and the recurrence rate was 10.9%. No depigmentation or scar formation was observed, and no patients reported any severe adverse events. All pregnancies resulted in healthy live birth without delivery complications. Conclusion: Cryotherapy combined with Lankefuning was a safe and effective procedure for the treatment of pregnant women with CA.