抑郁症与代谢综合征的神经内分泌免疫联系

随着社会竞争日益加剧,生活和工作节奏加快,人们所承受的压力和挑战(应激)也越来越大。长时间、高强度的应激会打破机体神经内分泌免疫网络原有的稳态,导致多种疾病的发生。近年来,抑郁症以其高发性、高致残性以及对家庭和社会的高负担而引起人们的高度重视,关于其发病机制和防治措施的研究方兴未艾。另外,在神经内分泌免疫紊乱的催生下,肥胖、糖尿病、高血脂、高血压等代谢相关问题也变得越发显著。近年来,愈来愈多的研究提示,抑郁症和代谢综合征的发病可能拥有共同的神经内分泌免疫基础,两类疾病也很可能在一定程度上互为因果。本文结合国内外研究现状,梳理总结相关研究成果,对两类疾病的神经内分泌免疫联系作一综述。

Neuroendocrine-immune Connection between Depression and Metabolic Syndrome

ABSTRACT: As social competition intensifies, the pace of life and work accelerates, people are exposed to more pressures and challenges (stress) in face of the fleeting opportunity. Persistent high-intensity stress can break the homeostasis of neuroendocrine-im- mune network, resulting in varies of diseases. In recent years, depression has caught high attention, with its high incidence, high disability rate and high burden of family and society. Studies on its pathogenesis and prevention are in the ascendant. While neuroendocrine-im- mune destabilizes, the incidence rate of obesity, diabetes, high cholesterol, hypertension and other metabolic-related issues are becoming increasingly severe. Current researches suggest that depression and metabolic syndrome may possess a common neuroendocrine immune basis; to some extent, they are likely to reinforce each other. In this review, we summarized the neuroendocrine-immune connection be- tween depression and metabolic syndrome.