经腹次全子宫切除术治疗子宫肌瘤的临床效果及对血清VEGF，IL-6，IL-8水平的影响

目的:探讨经腹次全子宫切除术治疗子宫肌瘤的临床效果及对血清血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平的影响。方法:选择我院2014年2月~2016年2月收治的106例子宫肌瘤患者,参照抽签法分作对照组与研究组。对照组采用经腹全子宫切除术治疗,研究组采用经腹次全子宫切除术治疗。比较两组的手术时间,出血量,肛门排气时间,住院时间,手术前后VEGF、IL-6、IL-8、促卵泡生成素(FSH)、雌二醇(E2)、抗苗勒管激素(AMH)水平的变化及并发症的发生情况。结果:研究组的手术时间、出血量、肛门排气时间、住院时间均明显短于对照组(P0.05)。手术前,两组血清VEGF、IL-6、IL-8、FSH、E2、AMH水平比较差异无统计学意义(P0.05);手术后,研究组血清IL-6、IL-8、E2、AMH水平明显低于对照组(P0.05),血清FSH水平明显高于对照组,差异具有统计学意义(P0.05),两组血清VEGF水平比较差异无统计学意义(P0.05)。研究组并发症的发生率显著低于对照组(P0.05)。结论:采用经腹次全子宫切除术治疗子宫肌瘤患者可起到与经腹全子宫切除术相似的应用效果,但经腹次全子宫切除术对机体形成的创伤较小,利于术后卵巢功能的恢复,可能与其降低患者术后血清IL-6、IL-8、VEGF水平有关。

Clinical Effect of Abdominal Total Hysterectomy on Uterine Fibroids and Serum VEGF, IL-6 and IL-8 Levels

ABSTRACT Objective: To research the clinical effect of abdominal total hysterectomy on the patients with uterine fibroids and the serum vascular endothelial growth factor (VEGF) and interleukin 6 (IL-6), interleukin 8 (IL-8) levels. Methods: 106 cases of patients with uterine fibroids from February 2014 to February 2016 were divided into the control group and the research group according to the lottery method, the control group was treated with total abdominal hysterectomy, while the research group was given abdominal total hysterecto- my treatment, the operation time, blood loss, anal exhaust time, length of hospital stay, changes of serum VEGF, IL-6, IL-8, Follicle stim- ulating hormone (FSH), estradiol (E2) levels, resistance to seedling le tube hormone (AMH) before and after the surgery as well as the oc- currence of complications were compared between two groups. Results: The operation time, blood loss, length of hospital stay, anal ex- haust time of research group were significantly shorter than those of the control group (P<0.05). Before surgery, the serum levels of VEGF, IL -6, IL-8, FSH, E2, AMH showed no difference between two groups (P>0.05). After the operation, the serum levels of IL-6, IL-8, E2, AMH of research group were lower than those of the control group (P<0.05), the serum level of FSH in research group was higher than that of the control group (P<0.05). The serum level of VEGF showed no difference between the two groups (P>0.05). The in- cidence rate of complications in research group was lower than that of the control group (P<0.05). Conclusion: Abdominal total hysterec- tomy showed similar effect with the abdominal hysterectomy in the treatment of uterine fibroids patients, but the abdominal full hysterec- tomy induced less trauma, promoted the recovery of ovarian function after surgery, which might be related to the decrease of serum IL-6, IL-8 and VEGF levels.