栓塞和夹闭治疗对颅内动脉瘤患者认知功能的影响

目的:评估血管内栓塞治疗和显微手术夹闭两种治疗方法对颅内动脉瘤患者认知功能的影响。方法:选取2014年3月至2015年9月重庆市中医院神经外科收治的颅内动脉瘤患者80例,按随机数字表法分为对照组和实验组各40例,对照组采用显微手术夹闭治疗,实验组采用血管内栓塞治疗。应用简易精神状态检查量表(MMSE)评估术后认知功能,并对比两组住院时间、院内死亡率和1年死亡率以及术后不良反应发生率。结果:实验组MMSE总分为(26.78±0.85)分,高于对照组的(22.25±0.63)分(P0.05);实验组认知功能障碍率为37.50%,低于对照组的55.00%(P0.05);实验组住院时间为(6.7±3.9)天,低于对照组的(9.6±4.5)天(P0.05),两组院内死亡率和1年死亡率比较无统计学差异(P0.05);两组术后不良反应发生率比较无统计学差异(P0.05)。结论:血管内介入治疗可改善颅内动脉瘤患者治疗后的认知功能,缩短住院时间。

Effects of Embolization and Clipping Therapy on Cognitive Function in Patients with Intracranial Aneurysms

ABSTRACT Objective: To evaluate the effects of endovascular embolization and microsurgical clipping on cognitive function in patients with intracranial aneurysm. Methods: A total of 80 patients with intracranial aneurysms, who were treated in Chongqing Hospital of Traditional Chinese Medicine from March 2014 to September 2015, were selected and randomly divided into control group(n=40) and experimental group (n=40).The control group was treated with microsurgical clipping, and the experimental group, with endovascular embolization. The postoperative cognitive function was assessed by the mini mental state examination scale (MMSE), and length of stay, in-hospital mortality rate, mortality rate in 1 year and the incidence of postoperative adverse reactions were compared between the two groups. Results: The total score(26.78±0.85) of MMSE in the experimental group was higher than that(22.25±0.63) of the control group (P<0.05). The cognitive dysfunction rate(37.50%) of the experimental group was lower than that(55.00%) of the control group (P<0.05). The length of stay[(6.7±3.9) days] of the experimental group was lower than that[(9.6±4.5) days] of the control group(P<0.05). There were no significant differences in in-hospital mortality rate and mortality rate in 1 year, and the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Endovascular interventional therapy can improve the cognitive function of the patients with intracranial aneurysms and shorten the length of hospital stay.