室性心律失常相关神经机制的研究进展

室性心律失常是常见的心血管系统疾病,指起源于心室的心律紊乱,其发病率高,严重影响人类健康。目前认为,器质性与非器质性心脏病引发的室性心律失常与神经功能调节密切相关,特别是中枢神经的调节作用;心力衰竭及心肌梗死引起的心律失常与神经内分泌系统紊乱相关;脑损伤或应激创伤引起的室性心律失常与自主神经所控制的区域有关。室性心律失常的电风暴属于临床急性危重性症候群,可引起严重的血流动力学障碍,通常需要采取电复律或电除颤进行紧急治疗,而该症状的主要的促发因素被认为是过度兴奋的交感神经状态。随着研究和临床实践的不断深入,我们对室性心律失常的发生机制会形成更加系统的认识,这对疾病防治手段的完善具有积极的意义。

Research and Progress in the Neural Mechanisms on Ventricular Arrhythmias

ABSTRACT: The ventricular arrhythmia is one of the common cardiological diseases which originates from the ventriculus cordis, with high death rate and harm to peoples''s health. So far, it is considered that the ventricular arrhythmias induced by the organic or non-organic heart diseases would be closely related to the neurological regulations, especially for the functions of central nervous system; The ventricular arrhythmias induced by Heart failure or myocardial infarction could be more likely related to the neuroendocrine system; and the ventricular arrhythmias induced by brain injury or stress might be directly related to the cross-linked autonomic nervous. Ventric- ular arrhythmia electrical storm belongs to the acute severe clinical syndrome that could cause severe hemodynamic disorder which need to be taken the electrical shock for emergency, and the main factor is considered to be the over-excited state of sympathetic nerve. With the deepening research and practice, the mechanisms of ventricular arrhythmia will have a better understanding and its means of preven- tion will also be improved.