O型孕妇产前IgG血型抗体效价与新生儿溶血病的相关性

目的:探讨O型孕妇产前IgG血型抗体效价与新生儿溶血病(HDN)的相关性。方法:选择2013年1月至2015年12月期间,在我院分娩的夫妻ABO血型不合的O型Rh(D)阳性孕妇432例及新生儿为研究对象,观察孕妇血清IgG抗体效价情况,新生儿HDN发病情况,并分析二者相关性。结果:432例孕妇中血清IgG抗A(B)效价大于或等于1:64的有189例,占43.75%,随IgG抗A(B)效价升高,孕妇比例逐渐减少。随孕次增加,孕妇血清IgG抗A(B)效价逐渐增高,各组孕妇血清IgG抗A(B)效价比较有统计学差异(P0.05)。随年龄增加,孕妇血清IgG抗A(B)效价逐渐增高,各组孕妇血清IgG抗A(B)效价比较有统计学差异(P0.05)。随IgG抗A(B)效价升高,HDN发生率显著升高,各组比较有统计学差异(P0.05)。等级相关检验显示,孕妇血清IgG抗A(B)与HDN发生呈正相关(r=0.732,P0.05)。结论:O型孕妇产前IgG血型抗体是引起HDN的主要原因,其水平与HDN呈正相关,值得临床重视。

The Correlation between the Titer of IgG Blood Group Antibody and Hemolytic Disease of Newborn in Type O Pregnant Women

ABSTRACT Objective: To investigate the correlation between the titer of IgG blood group antibody and hemolytic disease of new- born (HDN) in type O pregnant women. Methods: Selected 432 cases of type O Rh (D) positive pregnant women and neonate from Jan- uary 2013 to December 2015 in our hospital, maternal serum IgG antibody titer of observation, incidence of newborn HDN and analysis correlation. Results: In 432 cases of pregnant women, serum IgG anti A (B) titer is greater than or equal to 1:64 in 189 cases, accounting for 43.75%, with the IgG anti A (B) titer increased, the proportion of pregnant women gradually reduced. With the increase of pregnancy,pregnant women''s serum A anti IgG A (B) titer gradually increased, the serum levels of IgG anti A (B) in each group was statistically sig- nificant difference (P<0.05). With the increase of age,pregnant women''s serum A anti IgG A (B) gradually increased, the serum levels of IgG anti A (B) in each group was statistically significant difference (P<0.05). IgG (A) (B) titer increased, the incidence of HDN was sig- nificantly higher, there were statistically significant differences in each group (P<0.05). The grade correlation test showed that A (B) in the serum of pregnant women was positively correlated with HDN (r=0.732, P<0.05). Conclusion: The main cause of neonatal hemolytic disease is the O blood group antibody of IgG type pregnant women,which is positively correlated with the hemolytic disease of the new- born, which is worthy of clinical attention.