右归丸与液体钙片对老年骨质疏松症患者血清雌激素和骨钙素水平的影响

目的:研究右归丸联合液体钙片对老年骨质疏松症患者血清雌激素水平、骨钙素(BGP)水平及临床疗效的影响。方法:选取2014年10月至2015年9月本院收治的82例老年骨质疏松症患者,根据入院顺序分为观察组和对照组,每组41例。对照组使用骨化三醇软胶囊和液体钙软胶囊进行治疗,观察组在此基础上加以右归丸进行治疗。比较两组患者治疗前和治疗1个月后血清雌二醇(E2)水平、BGP水平、骨密度变化,分析两组患者的临床疗效。结果:治疗后,观察组的血清E2水平显著高于对照组(P0.05),BGP水平显著低于对照组(P0.05),腰椎L1-4正位、右侧股骨颈、左侧股骨颈骨密度显著高于对照组(p0.05),总临床疗效率显著高于对照组(P0.05)。结论:右归丸联合液体钙片治疗老年骨质疏松症患者能明显改善患者血清雌激素、BGP水平,增加骨密度,临床疗效良好。

Effect of Yougui Wan Combined with Liquid Calcium on the Serum Levels of Estrogen and Bone gla Protein in the Elderly Patients with Osteoporosis

ABSTRACT Objective: To study the clinical efficacy of yougui wan combined with liquid calcium in the treatment of elderly osteoporosis patients and the effect on levels of serum estrogen and bone gla protein(BGP). Methods: 82 elderly patients with osteoporosis who were treated in our hospital from October 2014 to September 2015 were selected as the object, according to the order of admission, those patients were divided into the observation group and control group, 41 cases in each group. The control group was treated with calcitriol soft capsule and liquid calcium soft capsule, and the observation group was treated with Yougui Wan on the basis of control group. The levels of serum estradiol (E2), BGP and bone mineral density (BMD) were compared between the two groups before and after treatment. The clinical efficacy of the two groups was analyzed. Results: After treatment, the E2 level in the observation group was significantly higher than that of the control group (P<0.05), the BGP level was significantly lower than that of the control group(P <0.05). The BMD of lumbar spine L1-4 orthostatic, right femoral neck, left femoral neck of observation group were significantly higher than those of the control group (P<0.05). The total clinical efficacy rate in the observation group was significantly higher than that of the control group (P<0.05). Conclusion: The combination of Yougui Wan and liquid calcium could improve the serum estrogen and BGP levels, increase the bone density, improve the clinical efficacy in the treatment of elderly patients with osteoporosis.