| 线粒体DNA异质性 |
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| 引用本文： | 巫小倩,张顺华,朱砺.线粒体DNA异质性[J].中国生物化学与分子生物学报,2017,33(1):11-16. |
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| 作者姓名： | 巫小倩 张顺华 朱砺 |
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| 作者单位： | 四川农业大学动物科技学院，成都611130 |
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| 基金项目： | 四川省教育厅科研项目（No.16ZB0038）和四川省科技厅项目（No. 16ZC2838）资助 |
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| 摘 要： | 线粒体 DNA（mitochondrial DNA，mtDNA）是线粒体内最重要的遗传物质。mtDNA 突变普 遍存在，突变型 mtDNA 与野生型 mtDNA 共存的现象被称为 mtDNA 异质性。mtDNA 异质性与衰老和多种疾病密切相关。mtDNA异质性特性、mtDNA 异质性与衰老和疾病相关性以及线粒体疾病的治疗等都是近年来遗传学研究的热点。本文从 mtDNA 异质性的动态变化、组织特异性、mtDNA 异质性与疾病以及线粒体疾病的治疗等方面对 mtDNA 异质性进行综述。
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| 关 键 词： | 异质性 动态变化 组织特异性 疾病 治疗 |
| 收稿时间： | 2016-08-30 |
Mitochondrial DNA Heteroplasmy |
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| WU Xiao-Qian,ZHANG Shun-Hua,ZHU Li.Mitochondrial DNA Heteroplasmy[J].Chinese Journal of Biochemistry and Molecular Biology,2017,33(1):11-16. |
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| Authors: | WU Xiao-Qian ZHANG Shun-Hua ZHU Li |
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| Institution: | College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China |
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| Abstract: | Mammal mitochondrial DNAs (mtDNAs) resident in mitochondria. mtDNA mutations are widespread. The co existence of the wild type and mutant mtDNAs is called mtDNA heteroplasmy. mtDNA heteroplasmy is closely related to aging and different diseases. Hitherto, characteristics of mtDNA heteroplasmy, the relationship between mtDNA heteroplasmy and aging, the correlation between mtDNA heteroplasmy and disease and the therapy of mitochondrial disease were all research hot pots. In this paper, we reviewed dynamics and tissue specificity of mtDNA heteroplasmy. And the relation between mtDNA heteroplasmy and aging, mtDNA heteroplasmy and disease and the therapy of mitochondrial disease were also summarized. |
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| Keywords: | mitochondrial DNA heteroplasmy dynamics tissue-specificity disease therapy |
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