化疗相关性闭经的影响因素及临床利弊

针对恶性肿瘤的化学治疗源于上世纪40年代Philips与Gilman第一次使用氮芥治疗恶性肿瘤,发展至今化疗在恶性肿瘤的治疗过程中已经取得了非常大的进步,成为恶性肿瘤的主要治疗方法之一。随着新药的逐渐研发和使用,已经使多数恶性肿瘤患者得到生存期的延长甚至是治愈。然而化疗导致的多种不良反应却日益受到越来越多的关注,如严重的骨髓抑制、心脏功能及结构的损伤、恶心、呕吐、腹泻、掉发等。化疗药物对多种身体多种器官系统都存在伤害,这其中因化疗引起的卵巢功能损伤导致的闭经是女性患者中最常见的,并且与治疗有关的不良事件之一。因化疗所导致的卵巢功能损害不仅严重影响患者的生活质量,而且还可能导致某些严重的疾病。因此探讨其发生规律和防治方法有重要意义。

Influencing Factors and Clinical Study for Chemotherapy-related Amenorrhea

Since the first application of nitrogen mustard into cancer treatment revealed by Gilman and Philips in 1940s, chemotherapy has made great progress to date and become an important treatment strategy for malignant tumors. With the development and research of new drugs, an increasing number of cancer patients has received long-term remission or cure. Therefore, more and more attentions have been paid to the adverse effects of chemotherapy drugs, such as bone marrow suppression, cardiac toxicity, gastrointestinal reactions and so on. Chemotherapy drugs are harmful to a variety of body organs, amenorrhea caused by chemotherapy-induced ovarian damage is one of the most common treatment-related adverse events for female patients. Chemotherapy-induced ovarian dysfunction affects not only the quality of life, but also the development of some serious diseases. So the exploration of its occurrence and prevention methods are important.