针刺联合黄连温胆汤治疗脑卒中后轻度认知功能障碍的临床疗效研究

目的:探讨针刺联合黄连温胆汤治疗脑卒中后轻度认知功能障碍的临床疗效。方法:选择2013年6月至2016年8月在我院进行治疗的脑卒中后轻度认知功能障碍患者100例,随机分为两组,每组50例。对照组患者服用尼莫地平,观察组患者在对照组基础上服用黄连温胆汤并配合针刺治疗。评价和比较两组患者治疗前后的简易精神状态量表(MMSE)以及改良爱丁堡-斯堪的纳维亚神经功能缺损评分量表(MSSS)评分,治疗后神经功能障碍和认知功能障碍的临床疗效及生活质量。结果:治疗后,两组患者的MMSE、ADL评分均较治疗前显著降低(P0.05),且观察组降低的程度显著高于对照组(P0.05);两组患者的MSSS、MBI评分显著升高(P0.05),且观察组升高程度显著高于对照组(P0.05)。观察组患者经治疗后的认知功能障碍及神经功能障碍临床疗效的总有效率均显著高于对照组(P0.05)。结论:黄连温胆汤联合针刺用于治疗脑卒中后轻度认知功能障碍临床疗效显著,且可显著改善患者生活质量。

The Curative Effect of Acupuncture Combined with Huanglian Wendan Decoction on the Mild Cognitive Impairment after Stroke

ABSTRACT Objective: To explore the curative effect of acupuncture combined with huanglian wendan decoction on the mild cog- nitive impairment after stroke. Methods: 100 patients with mild cognitive impairment after stroke were enrolled in our hospital from June 2013 to August 2016 and randomly divided into two groups. The control group (n=50) accepted nimodipine, and the study group (n=50) accepted huanglian wendan decoction combined with acupuncture treatment based on the control group. The MMSE and MSSS scores were evaluated and compared, and the improvement of cognitive dysfunction and nervous dysfunction, quality of life were compared and analyzed. Results: After treatment, the MMSE, ADL scores of patients were remarkably decreased compared with those before treatment (P<0.05), and the decreasing degree of study group was significantly higher than those of the control group(P<0.05). The MSSS, MBI scores of both groups were significantly increased compared with those before treatment (P<0.05), and the increasing degree of study group was significantly higher than those of the control group (P<0.05). The effective rates of improvement in cognitive dysfunction and nervous dysfunction, quality of life of study group were significantly higher than those of the control group (P<0.05). Conclusion: Huan- glian wendan decoction combined with acupuncture treatment was effective for the mild cognitive impairment after stroke and could im- prove the quality of life.