声弹性成像结合等硬度区域面积测量技术在离体血栓模型中的应用价值

目的:探讨一种声弹性成像定量分析方法用于评价深静脉血栓(DVT)患者血栓进展的情况。方法:经处理得12条大隐静脉标本,采用声弹性成像技术分别在1d、3d、6d、9d采集静脉标本中血凝块声弹性图像;应用等硬度区域面积测量技术(AMEHR)进行处理,计算血凝块区域在静脉标本中所占的比例,并进行数据分析。结果:经由AMEHR技术分析,在1d、3d、6d、9d静脉标本中,血凝块区所占比例分别为46.72%±12.16%,71.93%±7.24%,82.17%±5.17%,91.92%±3.69%。随着血栓时间的增加,血凝块区域所占比例逐渐增加,且差异有统计学意义(P0.05);随着时间的进展,血凝块增长的速率逐渐降低(1-3d:25.21%,3-6d:10.24%,6-9d:9.75%)。结论:AMEHR技术对血栓形成时间的评估上有一定的应用价值,有望为评估血栓形成时间提供参考。

Application Value of Elastography Combined with Area Measurement of Equal Hardness Region Program for the Thrombus Model in-vitro

ABSTRACT Objective: To investigate a novel elastography quantification approach for the evaluation of thrombus progression in deep vein thrombosis (DVT) patients. Methods: Twelve saphenous vein samples were harvested through operating and reorganizing. The elastography images of blood clots were obtained by elastography technology in 1 d, 3 d, 6 d and 9 d, respectively. AMEHR(Area Mea- surement of Equal Hardness Region) program was applied to analyze all images. The proportion of blood clots in images was calculated and analyzed. Results: Through the analysis of AMEHR, the proportion of blood clots were 46.72%±12.16%, 71.93%±7.24%, 82.17%±5.17% and 91.92%±3.69% in 1 d, 3 d, 6 d and 9 d, respectively. The proportion of blood clots increased during different time(P<0.05). As the time went by, the increasing rate of blood clots was gradually decreased, it was 25.21%, 10.24% and 9.75%, respectively. Conclusion: AMEHR technology was proved to be valuable to evaluate the thrombus progression, which was hoped to provide refer- ences for the determination of thrombus stage.