支气管镜下肺泡灌洗对难治性肺炎患者炎症介质和肺功能的影响

目的:探讨支气管镜下肺泡灌洗对难治性肺炎患者炎症介质和肺功能的影响。方法:选择2013年1月~2015年12月在我院进行诊治的难治性肺炎患者100例,随机分为两组。对照组采取常规的临床治疗,观察组在常规治疗基础上采用支气管镜联合支气管肺泡灌洗治疗。观察两组的治疗效果以及对患者炎症介质和肺功能的影响。结果:观察组的有效率为90.00%(45/50),明显高于对照组的76.00%(38/50)(P0.05)。治疗后,两组肺泡灌洗液中的内毒素、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和脂质过氧化物(LPO)水平均较治疗前明显降低(P0.05),且观察组降低的更为明显(P0.05);两组的肺功能均较治疗前明显改善(P0.05),且观察组改善的更为明显(P0.05)。结论:支气管镜下肺泡灌洗对难治性肺炎患者具有较好的治疗效果,可以有效降低炎症介质水平,并改善患者肺功能。

Effect of Bronchoalveolar Lavage on the Inflammatory Mediators and Pulmonary Function of Patients with Refractory Pneumonia

ABSTRACT Objective: To study the effect of bronchoscope lavage on the inflammatory mediators and pulmonary function of patients with refractory pneumonia. Methods: 100 cases of patients with refractory pneumonia who were treated in our hospital from Jan- uary 2010 to December 2015 were selected and randomly divided into two groups, the control group was treated with routine clinical treatment, and the observation group was treated with bronchoscope lavage. The curative effect and the changes of inflammatory media- tors and pulmonary function of the two groups after treatment were compared. Results: After treatment, the effective rate of observation group was 90.00%(45/50), which was significantly higher than that of the control group (76.00%, 38/50) (P<0.05); the levels of endotox- in, IL-6, TNF-2 and LPO in the bronchoalveolar lavage fluid of both groups were significantly decreased (P<0.05), which were decreased more significantly in the observation group (P<0.05), the pulmonary function of both groups were significantly improved(P<0.05), which improved more significantly in the observation group(P<0.05). Conclusion: Bronchoscope lavage had good therapeutic effect on the pa- tients with refractory pneumonia, it could effectively reduce the level of inflammatory mediators and improve the lung function.