康复训练联合阿托伐他汀对SIVD患者认知功能及日常行为能力的影响

目的:研究康复训练联合阿托伐他汀对SIVD患者认知功能及日常行为能力的影响。方法:选取97例确诊为SIVD的患者,根据随机数表法将所有患者分为观察组(n=48)和对照组(n=49),对照组给予口服多奈哌齐,观察组给予口服阿托伐他汀和康复训练。结果:治疗1个月后,观察组和对照组的MMSE、Mo CA、BI评分与治疗前差异均无统计学意义(P0.05);治疗6个月后,观察组的MMSE、Mo CA、BI评分显著高于治疗前(P0.05);观察组的MMSE、Mo CA、BI评分显著高于对照组(P0.001);观察组治疗1个月与6个月后总有效分别为16.6%与87.5%,高于同期对照组的12.24%(x~2=0.363,P=0.547)与53.06%(x~2=27.523,P0.001),差异无统计学意义。结论:康复训练联合阿托伐他汀能有效治疗SIVD,值得在临床中推广。

Effect of Rehabilitation Training Combined with Atorvastatin on Cognitive Function and Daily Behavior of Patients with SIVD

ABSTRACT Objective: To study the effect of rehabilitation training combined with atorvastatin on cognitive function and daily be- havior of patients with subcortical ischemic vascular dementia (SIVD). Methods: In our hospital from October 2013 to May 2016, 97 cases were diagnosed as SIVD patients, and they were divided into observation group (n=48) and control group (n=49) according to random number table method. Patients in the control group were given oral donepezil, and those in observation group were given oral atorvastatin and rehabilitation training. Montreal Cognitive Assessment (MoCA), Simple mental state examination (MMSE) and Barthel Index (BI) were adopted to record the changes after treatment. Results: After one month of treatment, the MMSE, MoCA and BI scores in observa- tion group and control group showed no significant difference, as compared with before treatment (P>0.05). After 6 months of treatment, the MMSE, MoCA and BI scores in observation group were significantly higher than those before treatment (P<0.05). As well, the MMSE, MoCA and BI scores were also significantly higher in observation group than in control group (P<0.001). In the observation group, the total effective rate was 16.6% after one month and 87.5% after 6 months. Both were respectively higher than those in the con- trol group (12.24%, x²=0.363, P=0.547; 53.06%, x²=27.523, P<0.001). Conclusion: Rehabilitation training combined with atorvastatin can effectively treat SIVD, so it is worth promoting in clinic.