| Dicer 的结构功能及其与肿瘤的关系 |
| |
| 引用本文： | 吴凌娟 陈鲤群. Dicer 的结构功能及其与肿瘤的关系[J]. 中国生物化学与分子生物学报, 2017, 33(1): 17-21. DOI: 10.13865/j.cnki.cjbmb.2017.01.03 |
| |
| 作者姓名： | 吴凌娟 陈鲤群 |
| |
| 作者单位： | 福州大学生物科学与工程学院，福州350108 |
| |
| 基金项目： | 国家自然科学基金项目（No.31500616），福建省教育厅科技项目一般项目（No.JA15093）资助 |
| |
| 摘 要： | Dicer蛋白是RNaseⅢ家族中重要的一员，对miRNA或siRNA的产生起着至关重要的作用。Dicer蛋白通常由1个DEXH盒子或H盒子、1个DUF283结构域、1个PAZ结构域、2个RNaseⅢ结构域(RNaseⅢa和RNaseⅢb)和1个dsRNA结合结构域组成。Dicer蛋白的分子结构决定了其在miRNAs合成中发挥着重要作用。Dicer及生成的miRNA与肿瘤又有着密切关系。本文主要针对Dicer及其与肿瘤的关系作简要综述。
|
| 关 键 词： | Dicer 结构 肿瘤 |
| 收稿时间： | 2016-10-12 |
Structure and Function of Dicer and Its Role in Tumor |
| |
| WU Ling-Juan,CHEN Li-Qun. Structure and Function of Dicer and Its Role in Tumor[J]. Chinese Journal of Biochemistry and Molecular Biology, 2017, 33(1): 17-21. DOI: 10.13865/j.cnki.cjbmb.2017.01.03 |
| |
| Authors: | WU Ling-Juan CHEN Li-Qun |
| |
| Affiliation: | Structure and Function of Dicer and Its Role in Tumor |
| |
| Abstract: | Dicer protein is one of the members of the RNaseⅢ family. Dicer is responsible for producing microRNA and small interfering RNA. Dicer comprises a DExD/H box helicase, a DUF283 domain, a PAZ domain, two RNaseⅢ domains (RNaseⅢa and RNaseⅢb) and a dsRNA binding domain (dsRBD). The role of Dicer in the synthesis of miRNAs is determined by its protein structure. In addition, Dicer protein and its generated miRNA are closely involved in tumor. This review aimed to provide an overview for the structure and function of Dicer and its role in tumor. |
| |
| Keywords: | Dicer structure tumor |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国生物化学与分子生物学报》浏览原始摘要信息 |
|
点击此处可从《中国生物化学与分子生物学报》下载全文 |
