罗哌卡因腰麻-硬膜外联合麻醉对剖宫产患者血清泌乳素水平的影响及其风险评估

目的:探讨罗哌卡因腰麻-硬膜外联合麻醉对剖宫产初产妇血清泌乳素水平的影响并评估其安全性。方法:收集我院就诊的90例剖宫产足月单胎初产妇,随机分为实验组和对照组,每组45例。实验组组均采用1%罗哌卡因1.5 mL+生理盐水1.5 mL,对照组产妇给予硬膜外麻醉。术后,比较两组产妇的泌乳素、感觉以及运动阻滞情况、麻醉效果以及不良反应发生率。结果:与手术前相比,两组产妇术后的泌乳素水平升高,且实验组产妇的泌乳素水平显著高于对照组(P0.05)。与对照组相比,实验组产妇感觉阻滞起效时间、运动阻滞起效时间较短,感觉恢复时间以及运动恢复时间较长,麻醉效果较好,不良反应的发生率较低(P0.05)。结论:罗哌卡因腰麻-硬膜外联合麻醉对剖宫产患者血清泌乳素水平的变化影响较硬膜外麻醉小,且麻醉效果及安全性更高。

Effects of Ropivacaine in CSEA on the Serum Prolactin Level of Cesarean Section Patients and Risk Assessment

ABSTRACT Objective: To investigate the effect of ropivacaine in combined spinal and epidural anesthesia for caesarean section on the maternal serum prolactin level and evaluate its safety. Methods: 90 cases of cesarean section in our hospital were randomly divided into the experimental group and control group, 45 cases in each group. The experiment group were treated with 1% ropivacaine hydrochloride 1.5ml+0.9% sodium chloride injection 1.5 mL, the control group was given epidural anesthesia. After the operation, the maternal prolactin, sensory and motor block, anesthesia effect and incidence of adverse reactions of the two groups were compared. Results: Compared with before surgery, the level of prolactin in both groups were increased, and the level of prolactin in the experimental group was significantly higher than that in the control group (P<0.05). Compared with the control group, the onset time of sensory block, motor block onset time were shorter in the experimental group, the sensory recovery time and motion recovery time were longer, the anesthesia effect was good, the incidence of adverse reactions was lower in the experimental group(P<0.05). Conclusion: Ropivacaine in combined spinal and epidural anesthesia for cesarean section changes of serum prolactin level in patients with the influence of epidural anesthesia, and the anesthetic effect and higher safety.