D-二聚体测定在慢性阻塞性肺疾病的疗效评价及预后意义的研究进展

慢性阻塞性肺疾病(简称慢阻肺)是一种呼吸科常见病,其并发症多,病死率高。在慢阻肺急加重期,细胞因子、炎症介质及内毒素首先损伤血管内皮,引发全身凝血功能障碍和负氮平衡。作为体内高凝状态和纤溶亢进的分子标志物之一,D-二聚体是交联纤维蛋白在纤溶酶作用下产生的一种特异性降解产物,其反映继发性纤溶活性意义。多项研究表明,D-二聚体水平对慢阻肺的治疗效果的评价及预后有重要意义。本文将通过总结D-二聚体的结构及与吸烟、年龄、血气分析及肺功能等方面的关系来阐述D-二聚体与慢阻肺相关性,并总结D-二聚体相关的慢阻肺的治疗方法及其对慢阻肺预后方面的相关意义。

Evaluation of Efficacy and Prognostic Significance of D-dimer in Patients with Chronic Obstructive Pulmonary Disease

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a respiratory disease, complications, mortality is high. In acute exacerbation of COPD, endotoxin, inflammatory mediators and cytokines first vascular endothelial injury, caused systemic coagulopathy and negative nitrogen balance. As in vivo coagulation State and fibrinolysis molecular marker of hyperthyroidism, d-dimer is d-dimer is the cross-linking of fibrin in the fibrinolytic enzyme producing a specific degradation product, which reflects the fibrinolytic activity in the secondary meaning. Several studies showed that d-dimer levels in the treatment of chronic obstructive pulmonary evaluation of the ef- fects and prognosis is important. This paper will summarize the d-dimer structure, age and smoking, arterial blood gas analysis and pul- monary function, and so on, instead of an aperture in d-dimer correlation with COPD, and d-dimer in the treatment of COPD and its rele- vance to the prognosis of chronic obstructive pulmonary.