前列地尔与益气复脉治疗老年心功能不全伴不稳定心绞痛的临床研究

目的:分析前列地尔与益气复脉治疗老年心功能不全伴不稳定心绞痛的临床效果。方法:选取2012年2月至2016年2月于我院诊治的心功能不全伴不稳定心绞痛老年患者300例,随机平均分为研究组和对照组各150例。对照组在常规治疗的基础上予以注射用益气复脉(冻干)治疗,研究组则在对照组基础上再予以前列地尔注射液治疗。分析比较两组患者的临床疗效、心电图疗效、心肌缺血发作情况以及心率、血流动力学指标的变化情况和不良反应的发生情况。结果:治疗后,研究组治疗后临床总有效率为96%,显著高于对照组(78%)(P0.05);研究组治疗后心电图总有效率为88%,显著高于对照组(64%)(P0.05);研究组心肌缺血的发作次数相比对照组降低程度更大,在各个时段以及总体的心肌缺血的平均发作次数均低于治疗前,且均低于对照组(P0.05);治疗后,两组患者的LVEF、CO、CI及MPI均明显升高(P0.05),而心率没有显著变化,研究组的LVEF、CO、CI及MPI显著高于对照组(P0.05);治疗期间,研究组的血管炎、血管疼痛的发生率显著高于对照组(P0.05),而其余不良反应发生率比较差异无统计学意义(P0.05)。结论:前列地尔与益气复脉治疗老年心功能不全伴不稳定心绞痛的疗效明显,可以减少心肌缺血的发作,改善血流动力学,且安全性高。

A Clinical Study on Alprostadil and YiqiFumai in the Treatment of Senile Cardiac Insufficiency with Unstable Angina Pectoris

ABSTRACT Objective: To analyze the clinical effect of alprostadil and YiqiFumaion on the elderly patients with cardiac insufficiency and unstable angina pectoris. Methods: 300 elderly patients who diagnosed as cardiac insufficiency associated with unstable angina from February 2012 to February 2016 in our hospital were randomly divided into the study group and the control group with 150 cases in each group. Based on the routine treatment, the control group was given YiqiFumaion treatment, while the study group was given alprostadil on the basis of control group. The clinical curative effect, electrocardiogram effect, myocardial ischemic attack, heart rate, and hemodynamics as well as the incidence of adverse reaction were analyzed and compared. Results: After treatment, the clinical efficacy and electrocardiogram of study group were better than those of the control group (P<0.05). The reduction degree of attacks of myocardial ischemia in the study group was much greater than that in the control group, and the average attacks of myocardial ischemia at each period and in total in the study group were lower than those in the control group (P<0.05). After treatment, the LVEF, CO, CI and MPI were all improved in both groups, which were significantly higher in the study group than those of the control group (P<0.05), but there was no significant change in the heart rate. During the treatment period, the incidence of vasculitis and vascular pain of study group was significantly higher than that of the control group (P<0.05), while the incidence of other adverse reactions showed no statistically significant difference (P>0.05). Conclusion: Alprostadil and YiqiFumai was effective in the treatment of elderly patients with cardiac insufficiency and unstable angina pectoris, which could relieve the attack of myocardial ischemia and improve the hemodynamics.