脂联素及其受体在乳腺癌中的表达及其与临床病理特征的相关性分析

目的:观察和分析脂联素(ADPN)及脂联素受体(adipo R)在乳腺癌中的表达及其与临床病理特征的相关性。方法:选取60例乳腺癌患者作为病例组,选取30例良性乳腺疾病患者作为对照组,对两组患者血清ADPN水平进行检测和比较。对病例组患者肿瘤组织及对照组患者病变组织中的ADPN、adipo R1、adipo R2表达水平进行检测和比较。对病例组患者的肿瘤原发部位、肿瘤结节数量、病理类型、肿瘤局部浸润情况、淋巴结转移情况、T分期、TNM分期情况及其与ADPN、adipo R1、adipo R2水平的关联性进行观察和分析。结果:病例组患者的血清ADPN水平及肿瘤乳腺组织中ADPN、adipo R1、adipo R2表达水平均显著低于对照组,两组之间的差异均有统计学意义(P0.05)。乳腺癌患者血清ADPN水平和乳腺组织中ADPN表达水平与肿瘤的局部浸润情况、T分期、淋巴结转移情况、TNM分期具有关联性(P0.05),乳腺癌患者乳腺组织中adipo R1和adipo R2表达水平与肿瘤的病理类型、局部浸润情况、T分期、淋巴结转移情况、TNM分期具有关联性(P0.05)。结论:乳腺癌患者外周血中的ADPN及肿瘤组织中的ADPN及其受体均呈现低表达,而且其表达水平与肿瘤的病理类型、浸润和转移情况及临床分期具有关联性,有望作为乳腺癌诊断和治疗的新型靶点。

Analysis on Expression of Adiponectin and Its Receptors in Breast Cancer and Its Correlation with Clinicopathological Features

ABSTRACT Objective: To observe and analyze expression of adiponectin (ADPN) and adiponectin receptors (adipoR) in breast cancer and its correlation with clinicopathological features. Methods: 60 cases of patients with breast cancer were selected as the case group. 30 cases of patients with benign breast diseases were selected as the control group. The serum level of ADPN of the patients in the two groups were detected and compared. The expressions of ADPN, adipoR1, adipoR2 in the tumor tissue of the patient in the case group and in the lesions of the patients in the control group were detected and compared. The primary tumor site, the tumor nodule number, the pathological type, the tumor infiltration, the lymph node metastasis, T staging, TNM staging of the patients in the case group and their correlation with the levels of ADPN, adipoR1, adipoR2 were observed and analyzed. Results: The serum ADPN level and the expressions of ADPN, adipoR1, adipoR2 in the tumor tissue of the patient in the case group were significantly lower than those in the control group. The differences between the two groups were statistically significant (P<0.05). The serum ADPN level and the expressions of ADPN in the tumor tissue of the patient with breast cancer were related with the tumor infiltration, the lymph node metastasis, T staging, TNM staging (P<0.05). The expressions of adipoR1 and adipoR2 in the tumor tissue of patients with breast cancer were related with the patho- logical type, the tumor infiltration, the lymph node metastasis, T staging and TNM staging (P<0.05). Conclusion: The ADPN and its re- ceptors in tumor tissues and peripheral blood of patients with breast cancer show low expressions, and have relevance with the pathologi- cal type, invasion and metastasis and clinical staging of the tumor and, which are expected to become new type of target for diagnosis and treatment of breast cancer.