2型糖尿病患者微血管病变与血清代谢学指标的关系

目的:探讨2型糖尿病(T2DM)患者微血管病变与血清代谢学指标的关系。方法:选择我院于2015年7月~2016年7月间收治的T2DM患者共96例,按是否存在微血管病变分为观察组(n=43,存在微血管病变)及对照组(n=53,无微血管病变)。检测并对比两组患者血清中三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FBG)、糖化血红蛋白(HbA1C)、同型半胱氨酸(Hcy)、血清胱抑素C(CysC)及血管内皮生长因子(VEGF)水平,并采用logistic回归分析T2DM微血管病变的危险因素。结果:观察组病程、吸烟率高于对照组,差异有统计学意义(P0.05);观察组TG、LDL、HbA1C、CysC、Hcy、VEGF水平均高于对照组,差异均有统计学意义(P0.05);两组TC、HDL水平比较,差异无统计学意义(P0.05);经logistic回归分析显示,病程、CysC、Hcy、VEGF为微血管病变的危险因素(OR=1.975,3.643,4.054,4.214,P0.05)。结论:CysC、Hcy、VEGF为微血管病变的危险因素,对其水平的检测有助于早期T2DM微血管病变诊断及治疗。

Relationship between Microvascular Lesions and Serum Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

ABSTRACT Objective: To investigate the relationship between microvascular lesions and serum metabolic parameters in patients with type 2 diabetes mellitus(T2DM). Methods: Selected 96 patients with T2DM in our hospital from July 2015 to July 2016, According to the presence of microvascular lesions were divided into observation group(n=43, with microvascular lesions)and control group(n=53,without microvascular lesions). Detected the levels of triacylglycerol(TG), total cholesterol(TC), high density lipoprotein(HDL), low den- sity lipoprotein (LDL), fasting blood glucose(FBG), glycosylated hemoglobin(HbA1C), homocysteine(Hcy)and serum cystatin C(CysC)and vascular endothelial growth factor(VEGF). Logistic regression analysis was used to analyze the risk factors of microvascular lesions. Results: Course of disease, smoking rate in observation group was higher than the control group, the difference was statistically signifi- cant(P<0.05); The levels of TG, LDL, HbA1C, CysC, Hcy, VEGF were higher than the control group, the differences were statistically significant(P<0.05), but the TC and HDL levels in two groups had no significant difference(P>0.05); Logistic regression analysis showed that the course of disease, CysC, Hcy, VEGF were the risk factors for microvascular lesions(OR=1.975, 3.643, 4.054, 4.214, P<0.05). Conclusion: CysC, Hcy, VEGF are the risk factors of the microvascular lesions, detecting these indexes is helpful to diagnosis and treat- ment of early T2DM with microvascular lesions.