左旋多巴联合综合疗法治疗屈光不正性弱视患儿的临床效果

目的:探究左旋多巴联合综合疗法治疗屈光不正性弱视患儿的临床效果。方法:选取2013年4月至2016年3月在我院接受治疗的屈光不正性弱视青少年103例(180眼),随机分为对照组52例(90眼)和观察组51例(90眼)。对照组患儿给予常规的综合治疗,观察组在对照组之上给予左旋多巴治疗。治疗6个月后,观察比较两组患儿的治疗有效率、图形视觉诱发电位(P-VEP)、视觉对比敏感度和视功能等以及不良反应的发生情况。结果:观察组的视力治疗有效率为90.00%,显著高于对照组(68.89%),差异具有统计学意义(P0.05)。治疗6个月后,两组的振幅出现明显的升高,且观察组显著高于对照组(P0.05);两组的潜伏期发生明显降低,且观察组的显著低于对照组(P0.05)。观察组患儿的100%、25%、10%及5%空间频率视觉对比敏感度均显著低于对照组(P0.05)。观察组患儿的矫正辐辏范围、矫正分开范围显著高于对照组,矫正近立体锐度显著低于对照组(P0.05)。治疗期间,两组不良反应发生情况比较差异无统计学意义(P0.05)。结论:左旋多巴联合综合疗法可有效改善屈光不正患儿的视觉中枢神经元功能,明显提高视力水平及视觉敏感度。

Clinical Efficacy of Levodopa Combined Comprehensive Therapy in the Treatment of Children with Ametropic Amblyopia

ABSTRACT Objective: To investigate the clinical efficacy of levodopa combined comprehensive therapy on the children with ametropic amblyopia. Methods: One hundred three patients (180 eyes) with ametropic amblyopia admitted into our hospital from April 2013 to March 2016 were randomly divided into the control group and the study group. Fifty-two patients (90 eyes) in the control group were treated with comprehensive therapy, and fifty-one patients (90 eyes) in study group were treated with levodopa combined compre- hensive therapy. After six months of treatment, the treatment efficacy, pattern visual evoked potential (P-VEP), visual sensitivity, and vi- sual function of patients were observed and compared between the two groups, and the adverse reaction were recorded and compared. Results: At six months after treatment, the effective rate of study group was 90.00%, which was significantly higher than that of control group(68.89%, P<0.05). The wave amplitude of P-VEP P100 of both groups showed a remarkable increase, which was much higher in the study group(P<0.05); the incubation period in both groups were obviously decreased, while they were markedly lower in the study group (P<0.05). The visual acuity under 100%, 25%, 10% and 5% of spatial frequency were conspicuously higher than those of control group (P<0.05). And correction convergence range, and correction separation range in study group were much higher than those of con- trol group, and corrected near stereo vision was markedly lower than that of control group (P<0.05). Additionally, no significant differ- ence was found in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Levodopa combined comprehensive therapy had a good ability of improving function of visual central neurons, visual acuity and binocular stereo vision functions.