来曲唑联合二甲双胍对多囊卵巢综合征患者血清胃生长素、性激素及血脂水平的影响及其临床疗效

目的:探讨来曲唑与二甲双胍治疗多囊卵巢综合征的临床效果及对患者血清胃生长素(ghrelin)、性激素及血脂水平的影响。方法:选择多囊卵巢综合征患者90例,均于2014年7月至2016年7月在本院接受治疗。根据治疗方法不同,将所选研究对象分为研究组与对照组,每组45例。对照组患者采用盐酸二甲双胍治疗,研究组患者在对照组基础上采用来曲唑片治疗。观察并比较两组患者治疗前后血清胃生长素(ghrelin)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)及高密度脂蛋白(HDL-C)水平,以及临床疗效。结果:研究组患者临床总有效率(88.9%)高于对照组(71.1%),差异具有统计学意义(P0.05);两组患者治疗后血清ghrelin水平均升高,且研究组高于对照组,差异具有统计学意义(P0.05);两组患者治疗后血清LH,E2及T水平均降低,且研究组低于对照组,差异具有统计学意义(P0.05);两组患者治疗后血清FSH水平比较,差异无统计学意义(P0.05);治疗后两组患者血清HDL-C水平均升高,且研究组高于对照组,差异具有统计学意义(P0.05);治疗后两组患者血清LDL-C,TC及TG水平均降低,且研究组低于对照组,差异具有统计学意义(P0.05)。结论:来曲唑联合二甲双胍治疗多囊卵巢综合征具有明显的临床效果,不仅可以改善患者卵巢功能及高雄激素状态,还能缓解患者高血脂症状,值得临床推广应用。

Effects of Letrozole and Metformin on Serum Levels of Ghrelin, Sex Hormones and Blood Lipids of Patients with Polycystic Ovary Syndrome and Its Clinical Efficacy

ABSTRACT Objective: To investigate the clinical effect of letrozole and metformin on serum levels of ghrelin, sex hormones and blood lipids of patients with polycystic ovary syndrome (PCOS) and its clinical efficacy. Methods: 90 patients with polycystic ovary syndrome who were treated in our hospital from July 2014 to July 2016 were selected and according to the different treatment methods, the patients were divided into the study group and the control group, with 45 cases in each group. The patients in the control group were treated with metformin hydrochloride, while the patients in the study group were treated with letrozol on the basis of the control group. Then serum levels of ghrelin, follicle stimulating hormone (FSH) and luteinizing hormone (LH), estradiol (E2), testosterone (T), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) and clinical efficacy between the two groups were observed and compared before and after the treatment. Results: The total effective rate in the study group was 88.9%, which was higher than 71.1% in the control group, and the difference was statistically significant (P<0.05); The serum levels of ghrelin of patients in the two groups increased after the treatment, and the study group was higher than that of the control group, and the differences were statistically significant (P<0.05); The serum levels of LH, E2 and T in the two groups decreased after the treatment, and the study group was lower than that of the control group, and the differences were statistically significant (P<0.05); There was no statistically significant difference about the FSH after treatment between the two groups (P>0.05); The serum levels of HDL-C in the two groups increased after the treatment, and the study group was higher than that of the control group, and the differences were statistically significant (P<0.05); The serum levels of LDL-C, TC and TG decreased in the two groups after the treatment, and the study group was lower than that of the control group, and the differences were statistically significant (P<0.05). Conclusion: Letrozole and metformin has obvious clinical effect om the treatment of polycystic ovary syndrome, which can improve the ovarian functions and hormonal status of kaohsiung, and relief the symptoms of hyperlipidemia, and it is worthy of clinical application.