结直肠癌无创筛查技术研究进展

结直肠癌和高危腺瘤的早期诊断及治疗,能够大大降低其死亡率。因而,在临床普及结直肠癌筛查有助于遏制该疾病的危害。目前,结肠镜检查是结直肠癌诊断的金标准,但该方法需要肠道准备,且具有侵入性,易造成肠道穿孔等缺点,导致患者依从性差,不利于其作为大规模筛查技术推广实施。近年来非侵入性的结直肠癌诊断方法发展迅速,这类方法主要通过检测粪便或血液样本中与结直肠癌发生相关的生物标志物,为结直肠癌的无创筛查提供了可能。但由于粪便、血液样本的成分复杂,对其中生物标志物的检测技术仍然在不断研究和完善中。本文分别从基于粪便样本和血液样本的检测技术两方面入手,探讨了近年来结直肠癌无创筛查技术的研究进展。

The Progress of Non-invasive Screening Methods for Colorectal Cancer

ABSTRACT: Early detection and treatment of high-risk adenomas and colorectal cancer (CRC) can reduce mortality of this disease. CRC screening is aimed at minimizing its harm and colonoscopy is presently the gold standard for it. However, colonoscopy needs bowel preparation and is invasive with high risk of intestinal perforation, causing a bad compliance, which is unfavorable to its popularization and application. Recently, non-invasive detection methods for CRC have gone through a rapid development. Tests based on CRC-related biomarkers in fecal and blood samples provide new options for non-invasive CRC screening. However, detection methods for these biomarkers still need further research and improvement because of the complex composition of feces and blood. In the two aspects of fe- cal tests and blood tests, the progress of recent studies on non-invasive screening methods for CRC was reviewed in this article.