卵母细胞透明带异常及其对助孕结局影响的研究进展

人类透明带(zona pellucida,ZP)是在卵泡发生过程中由卵母细胞和颗粒细胞共同分泌的由ZP1-ZP4四种糖蛋白分子组成的高度有序结构,它与卵母细胞的成熟、受精、胚胎发育及妊娠结局等预后紧密关联。许多生殖中心实验室发现有些患者的卵出现全部或部分的透明带异常,而且不同实验室发现的透明带异常类型各异。研究发现这些透明带异常与卵母细胞受精、胚胎发育及临床结局有一定的相关性。本文综述了关于透明带异常及其对卵母细胞受精、胚胎发育潜能和临床结局的影响的研究进展。

The Study Progress on the Relationship between Zona Pellucida and the Oocyte Fertilization, Embryo Development and the Pregnancy Outcome

ABSTRACT: The human zona pellucida (ZP) is a highly organized structure that is formed during folliculogenesis, and consists of four glycoproteins (ZP1-ZP4) which are secreted by oocytes and granulosa cells. The human ZP is a very vital structure related to oocyte maturation, normal fertilization, embryo development and pregnancy outcome. Many laboratories of assisted reproductive centers found that the oocytes of few patients exhibited abnormal zona pellucida, and the types of abnormal zona pellucida varied from laboratory to laboratory. Many studies found that these abnormal zona pellucida morphologies had a certain correlation with oocyte fertilization, em- bryo development and the clinical outcome.In this paper, the studies about the zona pellucida and their influence on the fertilization, em- bryo development potential and the pregnancy outcome were reviewed.