脊髓损伤的病理变化及治疗进展

脊髓损伤是中枢神经系统严重的创伤,多为脊柱损伤的最严重并发症之一,常造成损伤平面以下的肢体运动、感觉及植物神经功能紊乱,不仅给患者本人带来常人难以想象的心理痛苦及生活障碍,给家庭及社会同样带来高额的负担。近年来,脊髓损伤呈现出高发病率、高耗费、高致残率及低龄化的"三高一低"的发病趋势,逐渐成为学术界急需攻克的重大医疗问题。随着脊髓损伤病理生理机制的深入研究,针对发病机制不同阶段进行阻断的新药研究成为热点,加上干细胞技术及生物工程的发展,均为脊髓损伤后的治疗提供了新的方向。

Pathology and Treatment of Spinal Cord Injury

ABSTRACT: Spinal cord injury is a serious trauma of central nervous system. As one of the most serious complications of spinal in- jury, spinal cord injury often causes the limb movement, sensory and autonomic dysfunction of damage below, which not only brings un- imaginable psychological distress and life obstacles to the patients, but also causes high burden to the families and the community. In re- cent years, showing a incidence trend of high incidence, high cost, high morbidity and younger age, spinal cord injury has become ofne of themajor academic medical problems. The deep study of the pathophysiology of spinal cord injury, the drug research to block different stages of pathogenesis, and the development of bio-engineering, are provided a new direction of treatmet after spinal cord injury.