PRNP polymorphisms in Chinese ovine, caprine and bovine breeds |
| |
Authors: | Zhang L Li N Fan B Fang M Xu W |
| |
Affiliation: | National Laboratory for Agrobiotechnology, China Agricultural University, Yuanmingyuan West Road 2, Haidian District, Beijing 100094, P.R. China. |
| |
Abstract: | Transmissible spongiform encephalopathy (TSE) is a neurodegenerative disorder in humans and animals. Polymorphisms and mutations in the prion protein (PRNP) gene have been associated with the incidence of natural and experimental TSE and the incubation period length. In this study, we determined PRNP polymorphisms in Chinese ovine, caprine and bovine breeds using 400 samples from 13 ovine and caprine breeds and 250 samples from nine bovine breeds. In the ovine and caprine PRNP gene, we found five previously unreported amino acid polymorphisms and two silent nucleotide alterations. In bovine PRNP, we found eight previously unreported amino acid polymorphisms and six silent nucleotide alterations. |
| |
Keywords: | bovine caprine ovine polymorphism PRNP |
本文献已被 PubMed 等数据库收录! |
|