Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice |
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| Authors: | Kaoru Yoshida Akira Ochiai Hiroaki Matsuno Gabriel S Panayi Valerie M Corrigall |
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| Institution: | (1) Biomedical Engineering Center, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku Yokohama, 225-8502, Japan;(2) Department of Academic Rheumatology, King’s College London School of Medicine at Guy’s King’s and St Thomas’ Hospitals, CMCBI, 1st Floor New Hunts House, Guy’s Hospital Campus, London, SE1 9RT, UK |
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| Abstract: | Introduction Binding immunoglobulin protein (BiP) has previously shown powerful anti-inflammatory properties in the collagen-induced arthritis
(CIA) model, where a single dose of BiP has proved to be both a long-term prophylactic and therapeutic. In both CIA and human
in vitro studies, BiP induced regulatory T cells. The present investigation looked at the anti-inflammatory effect of BiP on inflamed
human synovial tissue transplanted into severe combined immunodeficient mice (SCID), a chimaeric in vivo model previously used to test the efficacy of biologic therapies. |
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