| 植物丝氨酸羧肽酶样酰基转移酶的结构、功能和应用 |
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| 引用本文： | 王宇,杨燕,刘忞之,王伟.植物丝氨酸羧肽酶样酰基转移酶的结构、功能和应用[J].生物工程学报,2021,37(6):1887-1899. |
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| 作者姓名： | 王宇 杨燕 刘忞之 王伟 |
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| 作者单位： | 中国医学科学院北京协和医学院药物研究所 天然药物活性物质与功能国家重点实验实验室/国家卫生健康委员会 天然药物生物合成重点实验室，北京 100050 |
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| 基金项目： | 中国医学科学院医学与健康科技创新工程项目 (No. 2016-I2M-3-012)，国家自然科学基金 (Nos. 81903487，82073757) 资助, 北京协和医学院合成生物学学科建设专项 (No. 201920100801)资助。 |
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| 摘 要： | 植物丝氨酸羧肽酶样酰基转移酶与丝氨酸羧肽酶相比具有相似的结构特点和很高的同源性,能够催化酰基葡萄糖酯的酰基转移反应,参与植物次生代谢产物的酰基化修饰,丰富天然产物结构多样性,改善化合物水溶性、稳定性等理化性质.本文重点介绍植物来源丝氨酸羧肽酶样酰基转移酶家族的结构特点、催化机制、功能鉴定及其生物催化应用等方面的研究进展...
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| 关 键 词： | 丝氨酸羧肽酶样酰基转移酶 酰基化反应 双功能酰基和糖基供体 生物催化 |
| 收稿时间： | 2021/3/3 0:00:00 |
Structure, function and application of serine carboxypeptidase-like acyltransferases from plants |
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| Yu Wang,Yan Yang,Minzhi Liu,Wei Wang.Structure, function and application of serine carboxypeptidase-like acyltransferases from plants[J].Chinese Journal of Biotechnology,2021,37(6):1887-1899. |
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| Authors: | Yu Wang Yan Yang Minzhi Liu Wei Wang |
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| Abstract: | Plant serine carboxypeptidase-like acyltransferases (SCPL-AT) have similar structural characteristics and high homology compared to the serine carboxypeptidase. They can transfer the acyl from acyl glucose esters to many natural products, participate in the acylation modification of plant secondary metabolites, enrich the structural diversity of natural products, and improve the physicochemical properties such as water solubility and stability of compounds. This review summarizes the structural characteristics, catalytic mechanism, functional characterization, and biocatalytic applications of SCPL-AT from plants. This will help to promote the functional characterization of these acyltransferase genes and the biosynthesis of useful plant secondary metabolites by synthetic biotechnology. |
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| Keywords: | serine carboxypeptidase-like acyltransferase acylation bifunctional acyl and glucosyl donor biocatalysis |
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