The design and synthesis of novel inhibitors of NADH:ubiquinone oxidoreductase |
| |
Authors: | Lindell Stephen D Ort Oswald Lümmen Peter Klein Robert |
| |
Institution: | Bayer CropScience GmbH, Werk H?chst, G836, D-65926, Frankfurt am Main, Germany. stephen.lindell@bayercropscience.com |
| |
Abstract: | Potent new inhibitors of NADH:ubiquinone oxidoreductase (complex I) have been designed, with the help of molecular modelling, by hybridisation of known complex I inhibitors with inhibitors of cytochrome c oxidoreductase. The most interesting compound was the chromone 7 which was a selective inhibitor of complex I (IC(50) 15 nM) and showed acaricidal activity against spider mites. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|