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Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants |
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| Authors: | Xiaorui Xing Lei Wang Zhen Cui Wangjun Fu Tao Zheng Lili Qin Pingju Ge Aidong Qian Nan Wang Shuai Yuan |
| Abstract: | Highlights 1 Deletion of residues 156–157 warps the neighboring beta-sheet and leads NTD and RBD to shift. 2 T859N stabilizes the packing of the 630 loop motif to make RBD standing transition more difficult. 3 The overall structures of the closed state S complex from different variants resemble each other. 4 Mutations in FPPR may affect the overall structure of the trimeric spike protein. |
| Keywords: | , , |
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