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Differential miRNA expression profiling of highly pathogenic avian influenza virus H5N1 infected chicken lungs reveals critical microRNAs,biological pathways and genes involved in the molecular pathogenesis |
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| Authors: | Anamika Mishra Muhasin Asaf Amod Kumar Diwakar Dattatreya Kulkarni Richa Sood Sandeep Bhatia Bharat Bhushan Ashwin Ashok Raut |
| Institution: | a Pathogenomics Laboratory, ICAR-National Institute of High Security Animal Diseases, OIE referral laboratory for Avian Influenza, Bhopal 462 021, India;b ICAR-National Institute of High Security Animal Diseases, OIE referral lab for Avian Influenza, Bhopal 462 021, India;c Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Bareilly 243 122, India |
| Abstract: | Highlights · Highthrouput sequencing of small RNA of H5N1 infected and mock infected chicken lungs. · 297 miRNAs identified in mock-infected and 201 miRNAs identified in AIV infected chicken lungs. · 36 miRNAs were upregulated and 90 were downregulated during H5N1 infection. · Functional analysis and gene ontology of predicted target genes of expressed miRNAs. · MAPK pathway, NF-κB, IGF and gga-let-7b might play important role during H5N1 pathogenesis. |
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