铁死亡参与脊髓损伤调控的研究进展

铁死亡是一种铁依赖性的，以细胞内脂质活性氧堆积为特征的细胞程序性死亡方式。广泛存在于肿瘤、癌症、急性肾损伤等多种疾病当中。脊髓损伤(spinal cord injury, SCI) 是一种严重的创伤性神经系统疾病，具有高发病率、高死亡率、高致残率的特点。目前，脊髓损伤的具体发生机制及高效治疗方法仍在探索当中，这也是亟待解决的世界性难题。研究表明，脊髓损伤后调控神经细胞的程序性死亡是治疗SCI的重点。然而，对于铁死亡参与脊髓损伤的分子生物学机制尚缺乏系统和深入的认识。收集和整理了近几年国内外有关脊髓损伤后铁死亡方面的相关文献，针对铁死亡参与脊髓损伤的调控机制和研究进展进行了综述，以期为治疗脊髓损伤带来新的思路。

Research Progress on the Regulatory Mechanism of Ferroptosis in Spinal Cord Injury

Ferroptosis is an iron-dependent， programmed cell death characterized by accumulation of intracellular lipid reactive oxygen species. It is widely existed in tumour， cancer， acute kidney injury and other diseases. Spinal cord injury （SCI） is a severe traumatic nervous system disease with high morbidity， mortality and disability. At present， the exact mechanism and efficient treatment of spinal cord injury are still being explored， which is also an urgent problem to be solved in the worldwide. Studies have shown that the regulation of programmed nerve cell death after spinal cord injury is the focus of treatment of SCI. However， the molecular mechanism of ferroptosis involved in spinal cord injury is not well understood. The paper collected and sorted out the domestic and foreign literature on ferroptosis after spinal cord injury in recent years， and reviewed the regulatory mechanism and research progress of ferroptosis involved in spinal cord injury， in order to bring new ideas for the treatment of spinal cord injury.