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The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer |
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| Authors: | Wei Ye Chuantao Ye Yongliang Hu Yangchao Dong Yingfeng Lei Fanglin Zhang |
| Institution: | a Department of Microbiology, School of Preclinical Medicine, Airforce Medical University:Fourth Military Medical University, Xi'an, 710032, China;b Department of Infectious Diseases, Tangdu Hospital, Airforce Medical University:Fourth Military Medical University, Xi'an, 710038, China;c Department of Dermatology, The Eighth Medical Center of PLA General Hospital, Beijing, 100091, China |
| Abstract: | Highlights 1. The structure of glycoprotein Gc, responsible for mediating membrane fusion between cell and CCHFV, is revealed, but many more mysteries remain. 2. Why do only antibodies against Gc have neutralizing effect, but not the one against Gn? 3. Why can NAbs against Gc only be protective in the animals in preventive settings, but not in the therapeutic administration? |
| Keywords: | , , , , |
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