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Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells |
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| Authors: | Yuanzhi Chen Chenguang Shen Jing Chen Junyu Chen Fentian Chen Limin Zhang Xue Liu Siyuan Chen Sen Xue Yongliang Liu Jixian Tang Quan Yuan Yixin Chen Wenxin Luo Ningshao Xia |
| Affiliation: | a National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health & School of Life Science, Xiamen University, Xiamen 361102, China; |
| Abstract: | Highlights 1. Class-switch recombination was mimicked in hybridomas through a controllable expression system of activation-induced cytidine deaminase. 2. IgG antibodies were generated through this system in an anti-Flu B IgM hybridoma 7G1. 3. IgG1 and IgG2a subtypes of 7G1 present improved antiviral activity in vitro and in vivo. |
| Keywords: | ; ; ; ; |
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