The action of antibiotics on the anaerobic digestion process |
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Authors: | J L Sanz N Rodríguez R Amils |
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Institution: | (1) Departamento de Biología Molecular, Universidad Autónoma de Madrid, Canto Blanco 28049 Madrid, Spain. Fax: 34 1 3978087 e-mail: JLSANZ@CCUAM3.SDI.UAM.ES, ES |
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Abstract: | Antibiotics can disturb the production of biogas during anaerobic digestion. This study shows a systematic approach to understanding
how the different bacterial populations involved in the final conversion of organic matter into methane are inhibited by 15
antimicrobial agents with different specificities and modes of action. The results obtained show the following trends: (i)
some inhibitors, such as the macrolide erythromycin, lack any inhibitory effect on biogas production; (ii) some antibiotics,
with different specificities, have partial inhibitory effects on anaerobic digestion and decrease methane production by interfering
with the activity of propionic-acid- and butyric-acid-degrading bacteria,␣(e.g. antibiotics that interfere with cell wall
synthesis, RNA polymerase activity and protein synthesis, especially the aminoglycosides); (iii) the protein synthesis inhibitors
chlortetracycline (IC50 40 mg l−1) and chloramphenicol (IC50 15–20 mg l−1) are very powerful inhibitors of anaerobic digestion. The majority of the antibiotics tested lacked activity against acetoclastic
methanogens, being active only on the acetogenic bacteria. However, chloramphenicol and chlortetracycline could cause the
complete inhibition of the acetoclastic methanogenic archaea.
Received: 6 February 1996 / Received revision: 24 July 1996 / Accepted: 5 August 1996 |
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