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Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype |
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| Authors: | Sara Pellegrino Nicola Ferri Noemi Colombo Edoardo Cremona Alberto Corsini Roberto Fanelli Maria Luisa Gelmi Chiara Cabrele |
| Affiliation: | 1. DISMAB—Dipartimento di Scienze Molecolari Applicate ai Biosistemi—Sez. Chimica Organica, Università degli Studi di Milano, I-20133 Milan, Italy;2. Dipartimento di Scienze Farmacologiche, Università degli Studi di Milano, I-20133 Milan, Italy;3. Fakultät für Chemie und Pharmazie, Universität Regensburg, D-93053 Regensburg, Germany;4. Fakultät für Chemie und Biochemie, Ruhr-Universität-Bochum, D-44801 Bochum, Germany |
| Abstract: | Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated α-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of α-actin and decreased Id protein levels. |
| Keywords: | Id proteins Protein domain recognition Helix– loop– helix Peptide dimerization Peptide mimic Solid-phase peptide synthesis Smooth muscle cell |
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