Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate,an analogue of 15R-lipoxin A4 |
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| Authors: | Phillips Eifion D Chang Hui-Fang Holmquist Christopher R McCauley John P |
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| Institution: | Department of Chemistry, AstraZeneca R&D Wilmington, 1800 Concord Pike, Wilmington, DE 19850, USA. eifion.phillips@astrazeneca.com |
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| Abstract: | We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A(4). |
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