Genomic comparisons of <Emphasis Type="Italic">Brucella</Emphasis> spp. and closely related bacteria using base compositional and proteome based methods |
| |
| Authors: | Jon Bohlin Lars Snipen Axel Cloeckaert Karin Lagesen David Ussery Anja B Kristoffersen Jacques Godfroid |
| |
| Institution: | 1.Department of Food Safety and Infection Biology, Epicenter,Norwegian School of Veterinary Science,Oslo,Norway;2.Department of Chemistry, Biotechnology and Food Sciences,Norwegian University of Life Sciences,?s,Norway;3.INRA, UR1282,Infectiologie Animale et Santé Publique, IASP,Nouzilly,France;4.Department of Informatics,University of Oslo,Oslo,Norway;5.Center for Biological Sequence Analysis, Department of Systems Biology, Comparative genomics unit,Technical University of Denmark,Lyngby,Denmark;6.National Veterinary Institute,Section for epidemiology,Sentrum,Oslo,Norway;7.Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology,Section of Arctic Veterinary Medicine,Troms?,Norway |
| |
| Abstract: | Background Classification of bacteria within the genus Brucella has been difficult due in part to considerable genomic homogeneity between the different species and biovars, in spite of
clear differences in phenotypes. Therefore, many different methods have been used to assess Brucella taxonomy. In the current work, we examine 32 sequenced genomes from genus Brucella representing the six classical species, as well as more recently described species, using bioinformatical methods. Comparisons
were made at the level of genomic DNA using oligonucleotide based methods (Markov chain based genomic signatures, genomic
codon and amino acid frequencies based comparisons) and proteomes (all-against-all BLAST protein comparisons and pan-genomic
analyses). |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
