Characteristics of Biofilms from Urinary Tract Catheters and Presence of Biofilm-Related Components in Escherichia coli |
| |
Authors: | Xiaoda Wang Heinrich Lünsdorf Ingrid Ehrén Annelie Brauner Ute Römling |
| |
Affiliation: | 1. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, FE 280, SE-171 77, Stockholm, Sweden 2. Department of Microbiology, Helmholtz Zentrum fur Infektionsforschung, Inhoffenstra?e 7, 38124, Braunschweig, Germany 3. Urology Department, Karolinska University Hospital, 171 76, Stockholm, Sweden 4. Clinical Microbiology, Karolinska University Hospital, 171 76, Stockholm, Sweden
|
| |
Abstract: | Long term catheterization of the urinary tract leads to bacterial colonization of the urine, whereby adherence to the catheter surface is a major determinative factor for colonization. Collection of bacterial isolates from urine and urinary catheters of 45 patients showed multi-species catheter-colonization, while Escherichia coli isolates were frequently found in the urine in high numbers. Biofilm formation of catheter and urine-derived E. coli isolates was associated with the presence of the fluA gene, loss of O-antigen, and expression of type 1 fimbriae. The second messenger cyclic di-GMP (cdiGMP), a major regulator of biofilm formation, regulated adherence to the catheter surface in a selected clinical isolate suggesting that the cdiGMP second messenger pathway may be a target for anti-biofilm therapeutic approaches. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|