Design,Synthesis, and Antifungal Activities of Novel 1,2,4‐Triazole Schiff Base Derivatives |
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Authors: | Ruyi Jin Jingli Liu Guanghui Zhang Jiajia Li Shuan Zhang Hui Guo |
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Institution: | College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an/Xianyang, P. R. China |
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Abstract: | With the aim to find new compounds with high antifungal activity, 21 4‐amino‐5‐substituted‐1,2,4‐triazole Schiff bases ( 2a – 2g , 3a – 3g , and 4a – 4g ) were designed and synthesized. Their antifungal activities against Pythium solani, Gibberlla nicotiancola, Fusarium oxysporium f. sp. niveum, Gibberlla saubinetii, Alternaria iycopersici, Phytophthora capsici, Physalospora piricola, Cercospora arachidicola hori, and Fusarium oxysporium f. sp. cucumber were tested, parts of the compounds exhibited excellent antifungal activity. This research provides useful information for further study of antifungal agents. |
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Keywords: | synthesis 1 2 4‐triazole Schiff base antifungal activities |
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