Salvisertin A,a New Hexacyclic Triterpenoid,and Other Bioactive Terpenes from Salvia deserta Root |
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| Authors: | Yin‐Ru Wang Yun Yu Shu‐Ming Li Wei Liu Wei Li Susan L Morris‐Natschke Masuo Goto Kuo‐Hsiung Lee Xue‐Feng Huang |
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| Institution: | 1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China;2. Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin, P. R. China;3. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, NC, USA;4. Department of Pharmacology, Nanjing Medical University, Nanjing, P. R. China;5. Chinese Medicinal Research and Development Center, China Medical University and Hospital, Taiwan, Taiwan |
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| Abstract: | Using various chromatographic methods, a new hexacyclic triterpenoid, 2β,3β,24β‐trihydroxy‐12,13‐cyclotaraxer‐l4‐en‐28oic acid ( 1 ), together with ten known compounds, 2α,3α,23‐trihydroxyurs‐12,20(30)‐dien‐28oic acid ( 2 ), 6,7‐dehydroroyleanone ( 3 ), horminone ( 4 ), 7‐O‐methylhorminone ( 5 ), sugiol ( 6 ), demethylcryptojaponol ( 7 ), 14‐deoxycoleon U ( 8 ), 5,6‐didehydro‐7‐hydroxy‐taxodone ( 9 ), ferruginol ( 10 ), and dichroanone ( 11 ), were isolated from the roots of Salvia deserta. Their structures were identified on the basis of spectroscopic analysis and comparison with the reported data. The individual compounds ( 1 , 3 – 8 ) were screened for cytotoxic activity, using the sulforhodamine B bioassay (SRB) method. As the results, Compounds 3 , 5 , and 8 showed cytotoxic potency against A549, MDA‐MB‐231, KB, KB‐VIN, and MCF7 cell lines with IC50 values ranging from 6.5 to 10.2 μm . |
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| Keywords: |
Salvia deserta
salvisertin A terpenes structure elucidation cytotoxic activity |
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