Naphthalene Derivatives and Quinones from Ventilago denticulata and Their Nitric Oxide Radical Scavenging,Antioxidant, Cytotoxic,Antibacterial, and Phosphodiesterase Inhibitory Activities |
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| Authors: | Wannapha Molee Anuchit Phanumartwiwath Chatchai Kesornpun Sanya Sureram Nattaya Ngamrojanavanich Kornkanok Ingkaninan Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop |
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| Affiliation: | 1. Chulabhorn Research Institute, Laksi, Bangkok, Thailand;2. Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand;3. Chulabhorn Graduate Institute, Chemical Biology Program, Chulabhorn Royal Academy, Laksi, Bangkok, Thailand;4. Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand;5. Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand;6. Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok, Thailand |
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| Abstract: | New naphthalene derivatives ( 1 and 2 ) and a new isomer ( 3 ) of ventilagolin, together with known anthraquinones, chrysophanol ( 4 ), physcion or emodin 3‐methyl ether ( 5 ), and emodin ( 6 ), were isolated from vines of Ventilago denticulata. The isolated compounds exhibited cytotoxic activity with IC50 values of 1.15 – 40.54 μg/ml. Compounds 1 – 3 selectively exhibited weak antibacterial activity (MIC values of 200.0 – 400.0 μg/ml), while emodin ( 6 ) displayed moderate antibacterial activity with MIC value of 25.0 μg/ml. The isolated compounds showed nitric oxide and DPPH radical scavenging activities. Compounds 1 – 3 and 6 exhibited weak xanthine oxidase inhibitory activity, while emodin ( 6 ) acted as an aromatase inhibitor with the IC50 value of 10.1 μm . Compounds 1 and 2 exhibited phosphodiesterase 5 inhibitory activity with IC50 values of 8.28 μm and 6.48 μm , respectively. |
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| Keywords: |
Ventilago denticulata
quinone radical scavenging activity cytotoxic activity antibacterial activity |
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