Antimicrobial Activity of Monoketone Curcuminoids Against Cariogenic Bacteria |
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| Authors: | Tatiana M Vieira Isabella A dos Santos Thayná S Silva Carlos H G Martins Antônio E M Crotti |
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| Institution: | 1. Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeir?o Preto, Universidade de S?o Paulo, Ribeir?o Preto, SP, Brazil;2. Laboratório de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Franca, SP, Brazil |
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| Abstract: | We evaluated the antimicrobial activity of 25 monoketone curcuminoids (MKCs) against a representative panel of cariogenic bacteria in terms of their minimum inhibitory concentration (MIC) values. Curcumin A ( 10 ) displayed promising activity against Streptococcus mutans (MIC = 50 μg/ml) and Streptococcus mitis (MIC = 50 μg/ml) as well as moderate activity against S. sanguinis (MIC = 100 μg/ml), Lactobacillus casei (MIC = 100 μg/ml), and Streptococcus salivarius (MIC = 200 μg/ml). Results indicated higher activity of compound 10 than that of its bis‐β‐diketone analog. Additionally, compounds 3a (1,5‐bis(4‐methylphenyl)pentan‐3‐one) and 7b (1,5‐bis(4‐bromophenyl)pentan‐3‐ol) were moderately active against S. mitis (MIC = 100 μg/ml) and S. salivarus (MIC = 200 μg/ml). |
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| Keywords: | cariogenic bacteria curcumin A monoketone curcuminoids oral pathogens
Streptococcus mutans
antimicrobial activities |
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