Two New Dolabrane Diterpenes from the Chinese Mangrove Ceriops tagal |
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| Authors: | Shu‐Jun Ni Jun Li Min‐Yi Li |
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| Institution: | 1. College of Pharmacy, Jinan University, Guangzhou, P. R. China;2. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China;3. Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China |
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| Abstract: | Two new dolabrane diterpenes, tagalenes J and K ( 1 and 2 ), together with eleven known analogues ( 3 – 13 ), were isolated from the ethanolic extract of the Chinese mangrove Ceriops tagal. The structures of these compounds were determined by extensive spectroscopic analysis, including 1D‐, 2D‐NMR and HR‐ESI‐MS, as well as the comparison with data in the literatures. Cytotoxicities of isolated compounds against MCF‐7, SW480, HepG2, HeLa, PANC‐1, and A2058 cancer cell lines were also evaluated. Compound 4 exhibited weak cytotoxic activity against SW480, HeLa, and PANC‐1 cell lines with IC50 values of 27.7, 22.2, and 17.6 μm , respectively. |
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| Keywords: | mangrove
Ceriops tagal
diterpenes dolabrane tagalenes J and K |
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