Tyrosinase Inhibitors from the Aerial Parts of Wulfenia carinthiaca Jacq. |
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| Authors: | Benjamin Mutschlechner Bettina Rainer Stefan Schwaiger Hermann Stuppner |
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| Institution: | 1. Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck (CMBI), Center for Chemistry and Biomedicine, University of Innsbruck, Innsbruck, Austria;2. MCI Management Center Innsbruck, Innsbruck, Austria |
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| Abstract: | Activity guided isolation of a MeOH extract of the aerial plant parts of Wulfenia carinthiaca Jacq . (Plantaginaceae), using a mushroom tyrosinase assay, resulted in the isolation of five phenylethanoid glucosides and four iridoid glycosides. Two of them, 2′‐O‐acetylisoplantamajoside and 2′,6″‐O‐diacetylisoplantamajoside, represent new natural products. Evaluation of the inhibitory activity of all isolated compounds revealed that the observed activity is not related to the isolated phenylethanoid glycosides but mainly due to the presence of the iridoid glycoside globularin (IC50 41.94 μm ; CI95% ± 16.61/11.89 μm ). Interestingly, structurally close related compounds (globularicisin, baldaccioside, and isoscrophularioside) showed no or only a weak tyrosinase inhibitory activity. |
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| Keywords: |
Wulfenia carinthiaca
Plantaginaceae mushroom tyrosinase inhibition (oxidoreductase) iridoid glycosides phenylethanoid glucosides |
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