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Two New Chromone Glycosides from the Roots of Saposhnikovia divaricata
Authors:Si‐Yuan Ma  Ling‐Gao Shi  Zheng‐Bing Gu  Yu‐Lan Wu  Liu‐Bin Wei  Qi‐Qiu Wei  Xing‐Ling Gao  Na Liao
Affiliation:1. College of Medicine, Guangxi University of Science and Technology, Liuzhou, P. R. China;2. College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning, P. R. China;3. Jiangsu Yongjian Pharmaceutical Technology Co. Ltd., Taizhou, P. R. China
Abstract:Five chromone glycosides were isolated from the water‐soluble portions of 70% EtOH extract of the roots of Saposhnikovia divaricata, including two new chromone glycosides 1 and 2 . The structures of the chromone glycosides were identified as (3′S)‐3′‐O‐β‐d ‐apiofuranosyl‐(1 → 6)‐β‐d ‐glucopyranosylhamaudol ( 1 ), (2′S)‐4′‐Oβ‐d ‐apiofuranosyl‐(1 → 6)‐β‐d ‐glucopyranosylvisamminol ( 2 ), 3′‐O‐glucopyranosylhamaudol ( 3 ), 4′‐O‐β‐d ‐glucopyranosylvisamminol ( 4 ), and 4′‐O‐β‐d ‐glucopyranosyl‐5‐O‐methylvisamminol ( 5 ) on the basis of extensive spectroscopic methods, and the absolute configurations of the new compounds were elucidated by the electronic circular dichroism (ECD) calculation and acid hydrolysis. The cytotoxic activities of the glycosides 1 – 5 against three human cancer cell lines (PC‐3, SK‐OV‐3, and H460) were evaluated. The result showed that compounds 1 – 5 had weak cytotoxic activities against the human cancer cell lines with IC50 values in the range of 48.54 ± 0.80 – 94.25 ± 1.45 μm .
Keywords:   Saposhnikovia divaricata     chromone  glycoside  ECD calculation  cytotoxic activities
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