Chemical Constituents of the Seed Cake of Camellia oleifera and Their Antioxidant and Antimelanogenic Activities |
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| Authors: | Wan‐Fang Zhu Ci‐Li Wang Feng Ye Hao‐Peng Sun Cong‐Yu Ma Wen‐Yuan Liu Feng Feng Masahiko Abe Toshihiro Akihisa Jie Zhang |
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| Affiliation: | 1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, P. R. China;2. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China;3. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, P. R. China;4. Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing, P. R. China;5. Jiangsu Food and Pharmaceutical Science College, Huaian, P. R. China;6. Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, Japan |
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| Abstract: | There is a growing interest in the exploitation of agricultural byproducts. This study explored the potential beneficial health effects from the main biowaste, tea seed pomace of Camellia oleifera Abel (Theaceae), produced when tea seed is processed. Eighteen compounds were isolated from the 70% EtOH extract of the seed cake of C. oleifera. Their structures were determined by ESI‐MS, 1H‐ and 13C‐NMR together with literature data. All fractions and compounds were evaluated for the antioxidant and melanogenesis inhibitory activities. As the result, AcOEt fraction has the best in vitro antioxidant and antimelanogenesis activities, compounds 7 – 12 and 15 showed remarkable antioxidant activity, compounds 4 , 6 , 8 , and 15 – 17 exhibited superior inhibitory activities against melanogenesis. Furthermore, tyrosinase inhibitory activity assay suggested that compound 8 could suppress melanogenesis by inhibiting the expression of tyrosinase. |
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| Keywords: | antioxidant activity melanogenesis inhibitor tyrosinase inhibitory activity seed cake of Camellia oleifera Abel chemical components |
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