Antiviral Triketone‐Phloroglucinol‐Monoterpene Adducts from Callistemon rigidus |
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| Authors: | Jia‐Qing Cao Yan Wu Yuan‐Lin Zhong Ni‐Ping Li Mu Chen Man‐Mei Li Wen‐Cai Ye Lei Wang |
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| Institution: | 1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China;2. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, P. R. China |
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| Abstract: | Callistrilones F – K ( 1 – 6 ), six new triketone‐phloroglucinol‐monoterpene hybrids were isolated from the twigs and leaves of Callistemon rigidus. Their structures with absolute configurations were established by a combination analysis of NMR spectra, X‐ray diffraction, and electronic circular dichroism (ECD) calculations. Compounds 3 and 4 exhibited moderate inhibitory activities against herpes simplex virus (HSV‐1) with IC50 values of 10.00 ± 2.50 and 12.50 ± 1.30 μm , respectively. |
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| Keywords: | callistrilones F – K
Callistemon rigidus
phloroglucinol derivatives antiviral activity |
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