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Synthesis of β‐Ketoamide Curcumin Analogs for Anti‐Diabetic and AGEs Inhibitory Activities
Authors:Govindharasu Banuppriya  Rajendran Sribalan  Sulthan Alavudeen Rizwan Fathima  Vediappen Padmini
Institution:Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India
Abstract:Two different series of novel β‐ketoamide curcumin analogs enriched in biological activities have been synthesized. The synthesized compounds were screened for their in vitro anti‐diabetic and AGEs inhibitory activities and exhibited potent to good anti‐diabetic and AGEs inhibitory activities. The molecular docking study was also performed with the α‐amylase enzyme.
Keywords:AGEs inhibitor  α  ‐amylase inhibition  α  ‐glucosidase inhibition  β  ‐ketoamide curcumin
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