Evaluation of In Vitro α‐Amylase and α‐Glucosidase Inhibitory Potentials of 14 Medicinal Plants Constituted in Thai Folk Antidiabetic Formularies |
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Authors: | Chonlatid Somtimuang Opeyemi Joshua Olatunji Chitchamai Ovatlarnporn |
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Affiliation: | 1. Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Thailand;2. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Thailand |
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Abstract: | The sporadic increase in the occurrence and prevalence of diabetes mellitus have compelled and vigorous search for alternative anti‐diabetic therapeutic approach from medicinal plants and its bioactive. One of the major approach employed is the reduction of gastrointestinal glucose levels through the inhibition of carbohydrate digesting enzymes notably α‐amylase and α‐glucosidase. In this study, the ethanol extracts of 14 selected plants from Mor Porn's recipe were screened for their α‐amylase and α‐glucosidase inhibitory activity. The ethanolic extract from the stem of Vitex glabrata displayed the highest percentage inhibitory activity of 84.98 ± 0.59 and 84.71 ± 1.51 against α‐glucosidase and α‐amylase enzymes, respectively. Chemical investigation of the active extract of V. glabrata indicated that pentacyclic triterpenes were the major compounds responsible for the activity. The result obtained from this study suggests the potential use of V. glabrata as an alternative natural source for the treatment of diabetes mellitus. |
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Keywords: | anti‐diabetic Vitex glabrata R.Br. α ‐amylase α ‐glucosidase Mor Porn's recipe diabetes |
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